Browsing by Author "Constantinou, Constantina"
Now showing items 1-9 of 9
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Caspase-independent pathways of programmed cell death: The unraveling of new targets of cancer therapy?
Constantinou, Constantina; Papas, Konstantinos A.; Constantinou, Andreas I. (2009)In the past few years, accumulating evidence in the literature supports the existence of pathways of caspase-independent programmed cell death (CI-PCD). These pathways are likely to be acting as 'death backup systems' that ...
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Article
Combining streaming media and collaborative elements to support lifelong learning
Constantinou, Constantina; Retalis, Symeon; Papadopoulos, George Angelos; Vrasidas, Charalambos (2009)This chapter presents the educational value of streaming media combined with asynchronous collaborative learning and describes the particular characteristics and the limitations of the supporting Asynchronous Multimedia ...
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Article
D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells
Neophytou, Christiana M.; Constantinou, Constantina; Papageorgis, P.; Constantinou, Andreas I. (2014)d-alpha-tocopheryl polyethylene glycol succinate (TPGS) is a vitamin E derivative that has been intensively applied as a vehicle for drug delivery systems to enhance drug solubility and increase the oral bioavailability ...
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HLA-B27 in the Greek Cypriot population: Distribution of subtypes in patients with ankylosing spondylitis and other HLA-B27-related diseases. The possible protective role of B*2707
Varnavidou-Nicolaidou, Agathi; Karpasitou, Katerina; Georgiou, Dora; Stylianou, Galatia; Kokkofitou, Avgousta; Christodoulides, Michalis; Constantinou, Constantina; Gregoriadou, Christiana; Kyriakides, George K. (2004)The major purpose of the present study was to investigate the frequency of human leukocyte antigen (HLA)-B27 alleles in healthy controls and in patients with ankylosing spondylitis (AS) and other HLA-B27-related diseases ...
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In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury
Constantinou, Constantina; Apidianakis, Yiorgos; Psychogios, N.; Righi, V.; Mindrinos, M. N.; Khan, N.; Swartz, H. M.; Szeto, H. H.; Tompkins, R. G.; Rahme, L. G.; Aria Tzika, A. (2016)Trauma is the most common cause of mortality among individuals aged between 1 and 44 years and the third leading cause of mortality overall in the US. In this study, we examined the effects of trauma on the expression of ...
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Induction of caspase-independent programmed cell death by vitamin E natural homologs and synthetic derivatives.
Constantinou, Constantina; Hyatt, John Anthony; Vraka, Panayiota S.; Papas, Andreas M.; Papas, Konstantinos A.; Neophytou, Christiana M.; Hadjivassiliou, V.; Constantinou, Andreas I. (2009)Current observations in the literature suggest that vitamin E may be a suitable candidate for cancer chemotherapy. To investigate this further, we examined the ability of the vitamin E natural homologs [alpha-, beta-, ...
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Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells
Nicolaou, Katerina A.; Liapis, Vasilios; Evdokiou, Andreas; Constantinou, Constantina; Magiatis, Prokopios; Skaltsounis, Alexios Leandros; Koumas, Laura; Costeas, Paul A.; Constantinou, Andreas I. (2012)Indirubin derivatives gained interest in recent years for their anticancer and antimetastatic properties. The objective of the present study was to evaluate and compare the anticancer properties of the two novel bromo-substituted ...
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Induction of DNA damage and caspase-independent programmed cell death by vitamin e
Constantinou, Constantina; Neophytou, Christiana M.; Vraka, Panayiota S.; Hyatt, John Anthony; Papas, Konstantinos A.; Constantinou, Andreas I. (2012)Vitamin E comprises 8 functionally unique isoforms and may be a suitable candidate for the adjuvant treatment of prostate cancer. In this study, we examined the ability of 2 vitamin E isoforms [α-tocotrienol (γ-TT) and ...
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Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs
Constantinou, Constantina; Papas, Andreas M.; Constantinou, Andreas I. (2008)Current observations in the literature suggest that vitamin E may be a suitable candidate for the adjuvant treatment of cancer. Even though historically most research focused on α-tocopherol, more recent evidence suggests ...